| 5. Round | 07/08/2021 | Banfield | - | Talleres de Córdoba | 0:1 | ||||
| 7. Round | 20/08/2021 | Banfield | - | Estudiantes | 1:1 |  |
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| 8. Round | 24/08/2021 | Patronato de Paraná | - | Banfield | 1:1 | ||||
| 9. Round | 28/08/2021 | Banfield | - | Platense | 2:4 | |
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| 10. Round | 05/09/2021 | Racing Club | - | Banfield | 0:0 | ||||
| 11. Round | 15/09/2021 | Banfield | - | Rosario Central | 1:2 | ||||
| 12. Round | 21/09/2021 | Defensa y Justicia | - | Banfield | 0:0 | ||||
| 13. Round | 25/09/2021 | Banfield | - | Atlético Tucumán | 2:0 | ||||
| 14. Round | 05/10/2021 | Colón de Santa Fe | - | Banfield | 0:0 | |
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| 18. Round | 24/10/2021 | Godoy Cruz | - | Banfield | 2:1 | ||||
| 19. Round | 30/10/2021 | Banfield | - | Vélez Sarsfield | 2:1 | |
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| 20. Round | 07/11/2021 | Gimnasia de La Plata | - | Banfield | 0:1 | ||||
| 21. Round | 19/11/2021 | Banfield | - | Aldosivi | 0:2 | ||||
| 22. Round | 24/11/2021 | Sarmiento de Junín | - | Banfield | 0:0 | ||||
| 24. Round | 07/12/2021 | Newell's Old Boys | - | Banfield | 0:0 | ||||
| 25. Round | 13/12/2021 | Banfield | - | Arsenal de Sarandí | 0:0 | |
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