| 5. Round | 03/10/2021 | UD San Fernando | - | CD San Roque de Lepe | 0:0 | ||||
| 6. Round | 10/10/2021 | Córdoba CF | - | UD San Fernando | 4:1 | ||||
| 19. Round | 30/01/2022 | UD Montijo | - | UD San Fernando | 2:0 |  |
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| 20. Round | 06/02/2022 | CD Mensajero | - | UD San Fernando | 2:0 | ||||
| 23. Round | 27/02/2022 | UD San Fernando | - | Córdoba CF | 3:0 dec. | ||||
| 24. Round | 06/03/2022 | CP Cacereño | - | UD San Fernando | 3:2 |  |
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| 25. Round | 13/03/2022 | UD San Fernando | - | CF Villanovense | 2:1 | ||||
| 18. Round | 16/03/2022 | UD San Fernando | - | UD Tamaraceite | 3:2 | ||||
| 28. Round | 03/04/2022 | CF Panadería Pulido | - | UD San Fernando | 1:1 | |
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| 29. Round | 10/04/2022 | UD San Fernando | - | AD Ceuta FC | 1:0 | ||||
| 30. Round | 17/04/2022 | Vélez CF | - | UD San Fernando | 3:0 | ||||
| 31. Round | 24/04/2022 | UD San Fernando | - | Xerez DFC | 0:1 | ||||
| 32. Round | 01/05/2022 | Cádiz CF B | - | UD San Fernando | 5:0 |
Spain