| 1. Round | 01/08/2005 | EA Guingamp | - | CS Sedan | 1:1 | ||||
| 2. Round | 05/08/2005 | FC Istres | - | EA Guingamp | 0:0 | ||||
| 3. Round | 12/08/2005 | EA Guingamp | - | FC Lorient | 1:1 |  |
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| 4. Round | 16/08/2005 | Dijon FCO | - | EA Guingamp | 1:2 | ||||
| 5. Round | 19/08/2005 | EA Guingamp | - | Grenoble Foot 38 | 0:1 | ||||
| 6. Round | 26/08/2005 | SM Caen | - | EA Guingamp | 0:0 | ||||
| 7. Round | 09/09/2005 | EA Guingamp | - | FC Gueugnon | 0:0 | ||||
| 8. Round | 16/09/2005 | US Créteil-Lusitanos | - | EA Guingamp | 2:1 | |
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| 9. Round | 23/09/2005 | EA Guingamp | - | SC Bastia | 0:1 | ||||
| 10. Round | 30/09/2005 | Montpellier HSC | - | EA Guingamp | 0:0 | ||||
| 11. Round | 07/10/2005 | EA Guingamp | - | Havre AC | 1:1 | ||||
| 12. Round | 17/10/2005 | Stade Brestois 29 | - | EA Guingamp | 2:1 | |
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| 13. Round | 21/10/2005 | EA Guingamp | - | LB Châteauroux | 0:1 | ||||
| 14. Round | 29/10/2005 | Stade de Reims | - | EA Guingamp | 0:0 | ||||
| 15. Round | 04/11/2005 | EA Guingamp | - | Valenciennes FC | 0:2 | ||||
| 16. Round | 11/11/2005 | Amiens SC | - | EA Guingamp | 0:2 | ||||
| 17. Round | 25/11/2005 | EA Guingamp | - | Stade Lavallois | 0:2 |
France