| 8. Round | 10/10/2021 | Tours FC [Youth] | - | Girondins Bordeaux [Youth] | 0:0 | ||||
| 9. Round | 16/10/2021 | Stade Rennais [Youth] | - | Tours FC [Youth] | 5:1 | ||||
| 11. Round | 14/11/2021 | Stade Brestois 29 [Youth] | - | Tours FC [Youth] | 4:1 | ||||
| 14. Round | 05/12/2021 | Le Mans FC [Youth] | - | Tours FC [Youth] | 4:1 | ||||
| 16. Round | 22/01/2022 | SA Mérignac [Youth] | - | Tours FC [Youth] | 3:0 | ||||
| 20. Round | 06/02/2022 | Tours FC [Youth] | - | US Concarneau [Youth] | 3:1 | ||||
| 21. Round | 13/02/2022 | USSA Vertou [Youth] | - | Tours FC [Youth] | 4:0 | ||||
| 22. Round | 05/03/2022 | Tours FC [Youth] | - | Stade Lavallois [Youth] | 1:3 | ||||
| 17. Round | 20/03/2022 | Girondins Bordeaux [Youth] | - | Tours FC [Youth] | 4:1 | ||||
| 18. Round | 26/03/2022 | Tours FC [Youth] | - | Stade Rennais [Youth] | 2:1 | ||||
| 23. Round | 10/04/2022 | Tours FC [Youth] | - | Stade Brestois 29 [Youth] | 0:0 | ||||
| 24. Round | 17/04/2022 | Angers SCO [Youth] | - | Tours FC [Youth] | 4:1 | ||||
| 25. Round | 01/05/2022 | EA Guingamp [Youth] | - | Tours FC [Youth] | 4:0 |
France