| 1. Round | 17/07/2021 | Newell's Old Boys | - | Talleres de Córdoba | 3:2 |  |
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| 2. Round | 27/07/2021 | Argentinos Juniors | - | Newell's Old Boys | 1:0 |  |
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| 4. Round | 02/08/2021 | Patronato de Paraná | - | Newell's Old Boys | 0:0 | ||||
| 5. Round | 07/08/2021 | Newell's Old Boys | - | Platense | 1:0 | ||||
| 6. Round | 16/08/2021 | Racing Club | - | Newell's Old Boys | 2:0 | ||||
| 7. Round | 22/08/2021 | Newell's Old Boys | - | Rosario Central | 1:1 | ||||
| 12. Round | 20/09/2021 | Lanús | - | Newell's Old Boys | 1:2 | ||||
| 13. Round | 28/09/2021 | Newell's Old Boys | - | Huracán | 0:1 | ||||
| 14. Round | 02/10/2021 | Godoy Cruz | - | Newell's Old Boys | 2:2 | |
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| 15. Round | 09/10/2021 | Newell's Old Boys | - | Vélez Sarsfield | 1:2 | ||||
| 16. Round | 16/10/2021 | Gimnasia de La Plata | - | Newell's Old Boys | 1:0 | ||||
| 17. Round | 21/10/2021 | Newell's Old Boys | - | Aldosivi | 0:0 | ||||
| 18. Round | 25/10/2021 | Sarmiento de Junín | - | Newell's Old Boys | 2:1 |
Argentina