| 1. Round | 08/08/2021 | Girondins Bordeaux | - | Clermont Foot 63 | 0:2 | ||||
| 2. Round | 15/08/2021 | Clermont Foot 63 | - | ESTAC Troyes | 2:0 | ||||
| 3. Round | 22/08/2021 | Olympique Lyonnais | - | Clermont Foot 63 | 3:3 | ||||
| 4. Round | 29/08/2021 | Clermont Foot 63 | - | FC Metz | 2:2 | ||||
| 5. Round | 11/09/2021 | Paris Saint-Germain | - | Clermont Foot 63 | 4:0 | ||||
| 7. Round | 22/09/2021 | Stade Rennais | - | Clermont Foot 63 | 6:0 | ||||
| 8. Round | 26/09/2021 | Clermont Foot 63 | - | AS Monaco | 1:3 | ||||
| 9. Round | 03/10/2021 | FC Lorient | - | Clermont Foot 63 | 1:1 | ||||
| 10. Round | 16/10/2021 | Clermont Foot 63 | - | Lille OSC | 1:0 | ||||
| 11. Round | 23/10/2021 | FC Nantes | - | Clermont Foot 63 | 2:1 | ||||
| 12. Round | 31/10/2021 | Clermont Foot 63 | - | Olympique Marseille | 0:1 | ||||
| 13. Round | 07/11/2021 | AS Saint-Étienne | - | Clermont Foot 63 | 3:2 | ||||
| 14. Round | 21/11/2021 | Clermont Foot 63 | - | OGC Nice | 1:2 | ||||
| 15. Round | 28/11/2021 | Stade de Reims | - | Clermont Foot 63 | 1:0 | ||||
| 18. Round | 12/12/2021 | Angers SCO | - | Clermont Foot 63 | 0:1 |
Uruguay
France