| 25. Round | 19/01/2010 | Leyton Orient | - | Yeovil Town | 2:0 | ||||
| 28. Round | 25/01/2010 | Charlton Athletic | - | Leyton Orient | 0:1 | ||||
| 29. Round | 30/01/2010 | Carlisle United | - | Leyton Orient | 2:2 | ||||
| 27. Round | 02/02/2010 | Leyton Orient | - | Bristol Rovers | 5:0 |  |
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| 30. Round | 06/02/2010 | Leyton Orient | - | Brighton & Hove Albion | 1:1 | ||||
| 31. Round | 13/02/2010 | Leyton Orient | - | Leeds United | 1:1 |  |
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| 32. Round | 20/02/2010 | Tranmere Rovers | - | Leyton Orient | 2:1 | |
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| 33. Round | 23/02/2010 | Gillingham FC | - | Leyton Orient | 1:1 | ||||
| 34. Round | 27/02/2010 | Leyton Orient | - | Swindon Town | 0:0 | ||||
| 35. Round | 06/03/2010 | Milton Keynes Dons | - | Leyton Orient | 1:0 | |
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| 26. Round | 09/03/2010 | Oldham Athletic | - | Leyton Orient | 2:0 | ||||
| 36. Round | 13/03/2010 | Leyton Orient | - | Walsall FC | 2:0 | ||||
| 37. Round | 20/03/2010 | Leyton Orient | - | Huddersfield Town | 0:2 | ||||
| 38. Round | 27/03/2010 | Brentford FC | - | Leyton Orient | 1:0 | |
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| 39. Round | 03/04/2010 | Leyton Orient | - | Hartlepool United | 1:3 | ||||
| 40. Round | 05/04/2010 | Southampton FC | - | Leyton Orient | 2:1 |
France