| 1. Round | 07/08/2021 | Trélissac FC | - | Moulins Yzeure Foot | 0:2 |  |
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| 3. Round | 21/08/2021 | Trélissac FC | - | Stade Montois | 3:1 | ||||
| 4. Round | 28/08/2021 | Bourges Foot 18 | - | Trélissac FC | 2:0 | ||||
| 5. Round | 04/09/2021 | Trélissac FC | - | Le Puy Foot 43 | 0:1 | ||||
| 6. Round | 11/09/2021 | Angers SCO B | - | Trélissac FC | 0:1 | ||||
| 15. Round | 14/01/2022 | Bergerac Périgord FC | - | Trélissac FC | 0:0 | ||||
| 20. Round | 05/03/2022 | Trélissac FC | - | Angers SCO B | 1:1 | ||||
| 22. Round | 19/03/2022 | Trélissac FC | - | Montpellier HSC B | 3:0 | ||||
| 25. Round | 16/04/2022 | US Colomiers | - | Trélissac FC | 1:1 |  |
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| 26. Round | 23/04/2022 | Trélissac FC | - | FC Nantes B | 1:0 |
France