| 2. Round | 14/08/2021 | GFA Rumilly Vallières | - | Marignane Gignac FC | 1:1 |  |
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| 3. Round | 21/08/2021 | Marignane Gignac FC | - | AS Saint-Priest | 0:1 | ||||
| 4. Round | 28/08/2021 | Étoile FC | - | Marignane Gignac FC | 2:0 | ||||
| 6. Round | 11/09/2021 | Aubagne FC | - | Marignane Gignac FC | 3:0 | ||||
| 11. Round | 06/11/2021 | RC Grasse | - | Marignane Gignac FC | 2:0 | ||||
| 12. Round | 20/11/2021 | Marignane Gignac FC | - | Louhans-Cuiseaux | 2:2 | ||||
| 1. Round | 18/12/2021 | Marignane Gignac FC | - | FC Martigues | 1:1 | ||||
| 24. Round | 09/04/2022 | Olympique Lyonnais B | - | Marignane Gignac FC | 3:1 | ||||
| 25. Round | 16/04/2022 | Marignane Gignac FC | - | RC Grasse | 1:2 | |
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| 26. Round | 23/04/2022 | Louhans-Cuiseaux | - | Marignane Gignac FC | 0:0 | ||||
| 27. Round | 29/04/2022 | Marignane Gignac FC | - | Hyères FC | 0:0 | ||||
| 28. Round | 14/05/2022 | Lyon-La Duchère | - | Marignane Gignac FC | 3:1 | ||||
| 29. Round | 21/05/2022 | Marignane Gignac FC | - | AS Monaco B | 0:3 | ||||
| 30. Round | 28/05/2022 | FC Martigues | - | Marignane Gignac FC | 3:0 |
France