| 1. Round | 17/10/2020 | Sporting Gijón B | - | Cultural Leonesa | 2:4 | ||||
| 3. Round | 01/11/2020 | CD Lealtad | - | Cultural Leonesa | 1:0 | ||||
| 4. Round | 08/11/2020 | Cultural Leonesa | - | Real Oviedo B | 2:1 | ||||
| 6. Round | 29/11/2020 | Cultural Leonesa | - | Burgos CF | 1:1 |  |
|||
| 9. Round | 09/01/2021 | Marino de Luanco | - | Cultural Leonesa | 0:2 | ||||
| 12. Round | 31/01/2021 | Cultural Leonesa | - | CD Lealtad | 0:0 | ||||
| 18. Round | 21/03/2021 | Cultural Leonesa | - | Marino de Luanco | 2:0 |
Spain