| 1. Round | 03/09/2022 | FC Cartagena B | - | Real Betis B | 0:1 | ||||
| 2. Round | 11/09/2022 | Atlético Sanluqueño CF | - | FC Cartagena B | 1:0 | ||||
| 3. Round | 18/09/2022 | FC Cartagena B | - | Cádiz CF B | 1:1 | ||||
| 4. Round | 25/09/2022 | Antequera CF | - | FC Cartagena B | 2:0 | ||||
| 5. Round | 02/10/2022 | FC Cartagena B | - | CD El Ejido 2012 | 1:0 | ||||
| 6. Round | 09/10/2022 | Recreativo Granada | - | FC Cartagena B | 1:2 | ||||
| 7. Round | 16/10/2022 | Utrera CD | - | FC Cartagena B | 3:2 | ||||
| 8. Round | 23/10/2022 | FC Cartagena B | - | Mar Menor CF | 1:1 | ||||
| 9. Round | 30/10/2022 | Recreativo Huelva | - | FC Cartagena B | 1:0 | ||||
| 10. Round | 05/11/2022 | FC Cartagena B | - | Sevilla Atlético | 1:0 | ||||
| 11. Round | 20/11/2022 | Xerez DFC | - | FC Cartagena B | 0:2 | ||||
| 12. Round | 27/11/2022 | FC Cartagena B | - | Vélez CF | 2:1 | ||||
| 15. Round | 18/12/2022 | UCAM Murcia CF | - | FC Cartagena B | 6:1 |
Spain