| 1. Round | 29/08/2021 | EA Guingamp [Youth B] | - | Angoulême CFC [Youth B] | 5:1 | ||||
| 2. Round | 05/09/2021 | Vannes OC [Youth B] | - | EA Guingamp [Youth B] | 0:3 |  |
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| 3. Round | 11/09/2021 | EA Guingamp [Youth B] | - | FC Nantes [Youth B] | 1:4 | ||||
| 4. Round | 19/09/2021 | Angers SCO [Youth B] | - | EA Guingamp [Youth B] | 7:0 | ||||
| 17. Round | 12/02/2022 | LB Châteauroux [Youth B] | - | EA Guingamp [Youth B] | 2:2 | ||||
| 21. Round | 27/03/2022 | Stade brestois 29 [Youth B] | - | EA Guingamp [Youth B] | 1:0 | ||||
| 24. Round | 17/04/2022 | La Roche VF [Youth B] | - | EA Guingamp [Youth B] | 0:2 |
France