| 2. Round | 17/01/2021 | Santos Laguna [U17] | - | UANL Tigres [U17] | 2:3 | ||||
| 3. Round | 22/01/2021 | Mazatlán FC [U17] | - | Santos Laguna [U17] | 2:2 |  |
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| 4. Round | 31/01/2021 | Santos Laguna [U17] | - | CF América [U17] | 4:2 | |
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| 5. Round | 06/02/2021 | Atlas Guadalajara [U17] | - | Santos Laguna [U17] | 1:3 | |
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| 6. Round | 14/02/2021 | Santos Laguna [U17] | - | CF Monterrey [U17] | 2:1 | ||||
| 7. Round | 18/02/2021 | Atlético San Luis [U17] | - | Santos Laguna [U17] | 0:1 |  |
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| 9. Round | 04/03/2021 | Pumas UNAM [U17] | - | Santos Laguna [U17] | 2:1 | ||||
| 10. Round | 07/03/2021 | Santos Laguna [U17] | - | Club Necaxa [U17] | 2:1 | |
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| 11. Round | 13/03/2021 | Club Tijuana [U17] | - | Santos Laguna [U17] | 3:1 | |
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| 12. Round | 21/03/2021 | Santos Laguna [U17] | - | Club León [U17] | 1:1 | |
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| 1. Round | 26/03/2021 | Santos Laguna [U17] | - | Cruz Azul [U17] | 4:1 | |
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| 13. Round | 04/04/2021 | Deportivo Guadalajara [U17] | - | Santos Laguna [U17] | 2:0 | ||||
| 14. Round | 11/04/2021 | Gallos Blancos [U17] | - | Santos Laguna [U17] | 0:0 |  |
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| 16. Round | 26/04/2021 | CF Pachuca [U17] | - | Santos Laguna [U17] | 4:2 | |
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| 17. Round | 02/05/2021 | Santos Laguna [U17] | - | Puebla FC [U17] | 1:0 |
Mexico