| 6. Round | 31/07/2022 | Santos Laguna [U20] | - | Atlas Guadalajara [U20] | 1:1 |  |
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| 1. Round | 03/08/2022 | Santos Laguna [U20] | - | CF Monterrey [U20] | 2:1 | ||||
| 7. Round | 06/08/2022 | Santos Laguna [U20] | - | Cruz Azul [U20] | 2:1 | |
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| 8. Round | 14/08/2022 | UANL Tigres [U20] | - | Santos Laguna [U20] | 2:2 | |
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| 9. Round | 18/08/2022 | Santos Laguna [U20] | - | Club León [U20] | 2:3 | ||||
| 10. Round | 21/08/2022 | Pumas UNAM [U20] | - | Santos Laguna [U20] | 0:1 |  |
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| 16. Round | 25/08/2022 | Club Tijuana [U20] | - | Santos Laguna [U20] | 1:1 | ||||
| 11. Round | 28/08/2022 | Santos Laguna [U20] | - | Atlético San Luis [U20] | 7:2 | |
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| 12. Round | 03/09/2022 | CF Pachuca [U20] | - | Santos Laguna [U20] | 5:1 | ||||
| 13. Round | 06/09/2022 | Santos Laguna [U20] | - | Club Necaxa [U20] | 3:2 | |
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| 14. Round | 10/09/2022 | Gallos Blancos [U20] | - | Santos Laguna [U20] | 2:2 | |
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| 15. Round | 18/09/2022 | Santos Laguna [U20] | - | FC Juárez [U20] | 3:0 | ||||
| 17. Round | 02/10/2022 | Santos Laguna [U20] | - | Mazatlán FC [U20] | 2:3 |
Mexico