| 4. Round | 26/01/2023 | Atlas Guadalajara [U20] | - | Santos Laguna [U20] | 1:2 | ||||
| 5. Round | 04/02/2023 | Santos Laguna [U20] | - | CF América [U20] | 0:1 | ||||
| 6. Round | 10/02/2023 | FC Juárez [U20] | - | Santos Laguna [U20] | 1:0 | ||||
| 8. Round | 18/02/2023 | Atlético San Luis [U20] | - | Santos Laguna [U20] | 0:1 | ||||
| 10. Round | 04/03/2023 | Deportivo Guadalajara [U20] | - | Santos Laguna [U20] | 1:0 |  |
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| 12. Round | 19/03/2023 | Club León [U20] | - | Santos Laguna [U20] | 1:3 |  |
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| 14. Round | 09/04/2023 | Santos Laguna [U20] | - | CF Pachuca [U20] | 1:3 | ||||
| 15. Round | 16/04/2023 | CF Monterrey [U20] | - | Santos Laguna [U20] | 2:1 | ||||
| 7. Round | 19/04/2023 | Santos Laguna [U20] | - | Deportivo Toluca [U20] | 2:1 | |
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| 17. Round | 29/04/2023 | Cruz Azul [U20] | - | Santos Laguna [U20] | 2:1 |
Mexico