| 10. Round | 15/10/2021 | Paris Saint-Germain | - | Angers SCO | 2:1 | ||||
| 12. Round | 29/10/2021 | Paris Saint-Germain | - | Lille OSC | 2:1 | ||||
| 13. Round | 06/11/2021 | Girondins Bordeaux | - | Paris Saint-Germain | 2:3 | ||||
| 14. Round | 20/11/2021 | Paris Saint-Germain | - | FC Nantes | 3:1 | ||||
| 15. Round | 28/11/2021 | AS Saint-Étienne | - | Paris Saint-Germain | 1:3 |  |
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| 17. Round | 04/12/2021 | RC Lens | - | Paris Saint-Germain | 1:1 | ||||
| 18. Round | 12/12/2021 | Paris Saint-Germain | - | AS Monaco | 2:0 | ||||
| 24. Round | 11/02/2022 | Paris Saint-Germain | - | Stade Rennais | 1:0 | ||||
| 25. Round | 19/02/2022 | FC Nantes | - | Paris Saint-Germain | 3:1 | ||||
| 26. Round | 26/02/2022 | Paris Saint-Germain | - | AS Saint-Étienne | 3:1 | ||||
| 27. Round | 05/03/2022 | OGC Nice | - | Paris Saint-Germain | 1:0 | ||||
| 31. Round | 09/04/2022 | Clermont Foot 63 | - | Paris Saint-Germain | 1:6 | ||||
| 33. Round | 20/04/2022 | Angers SCO | - | Paris Saint-Germain | 0:3 | |
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| 35. Round | 29/04/2022 | RC Strasbourg | - | Paris Saint-Germain | 3:3 | ||||
| 37. Round | 14/05/2022 | Montpellier HSC | - | Paris Saint-Germain | 0:4 |
Spain
