| 3. Round | 07/08/2021 | CF América [U18] | - | Puebla FC [U18] | 1:0 | ||||
| 4. Round | 15/08/2021 | Atlas Guadalajara [U18] | - | CF América [U18] | 1:3 |  |
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| 5. Round | 18/08/2021 | FC Juárez [U18] | - | CF América [U18] | 2:2 | ||||
| 6. Round | 22/08/2021 | CF América [U18] | - | Club Tijuana [U18] | 4:0 | |
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| 7. Round | 28/08/2021 | Club León [U18] | - | CF América [U18] | 0:1 | ||||
| 8. Round | 11/09/2021 | CF América [U18] | - | Mazatlán FC [U18] | 2:1 | ||||
| 14. Round | 15/09/2021 | CF América [U18] | - | Santos Laguna [U18] | 0:1 | ||||
| 9. Round | 18/09/2021 | Deportivo Toluca [U18] | - | CF América [U18] | 0:1 | ||||
| 10. Round | 25/09/2021 | CF América [U18] | - | Deportivo Guadalajara [U18] | 5:1 | |
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| 11. Round | 28/09/2021 | CF Pachuca [U18] | - | CF América [U18] | 4:1 | |
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| 12. Round | 03/10/2021 | CF América [U18] | - | Pumas UNAM [U18] | 1:0 | ||||
| 13. Round | 16/10/2021 | Atlético San Luis [U18] | - | CF América [U18] | 1:1 | ||||
| 15. Round | 23/10/2021 | CF América [U18] | - | UANL Tigres [U18] | 3:3 | ||||
| 16. Round | 31/10/2021 | Cruz Azul [U18] | - | CF América [U18] | 0:0 | ||||
| 17. Round | 06/11/2021 | CF América [U18] | - | CF Monterrey [U18] | 2:0 | |
Mexico