| 1. Round | 13/09/2020 | Villarreal CF | - | SD Huesca | 1:1 | ||||
| 2. Round | 20/09/2020 | SD Huesca | - | Cádiz CF | 0:2 | ||||
| 3. Round | 26/09/2020 | Valencia CF | - | SD Huesca | 1:1 | ||||
| 4. Round | 30/09/2020 | SD Huesca | - | Atlético Madrid | 0:0 | ||||
| 5. Round | 03/10/2020 | Elche CF | - | SD Huesca | 0:0 | ||||
| 9. Round | 07/11/2020 | SD Huesca | - | SD Eibar | 1:1 | ||||
| 10. Round | 20/11/2020 | CA Osasuna | - | SD Huesca | 1:1 | ||||
| 12. Round | 06/12/2020 | Granada CF | - | SD Huesca | 3:3 | ||||
| 15. Round | 22/12/2020 | SD Huesca | - | Levante UD | 1:1 | ||||
| 16. Round | 30/12/2020 | RC Celta | - | SD Huesca | 2:1 | ||||
| 17. Round | 03/01/2021 | SD Huesca | - | FC Barcelona | 0:1 | ||||
| 22. Round | 06/02/2021 | SD Huesca | - | Real Madrid | 1:2 | ||||
| 23. Round | 13/02/2021 | Sevilla FC | - | SD Huesca | 1:0 | ||||
| 24. Round | 21/02/2021 | SD Huesca | - | Granada CF | 3:2 | ||||
| 26. Round | 07/03/2021 | SD Huesca | - | RC Celta | 3:4 |
Spain