| 3. Round | 27/08/2021 | UD Las Palmas | - | SD Huesca | 2:1 | ||||
| 4. Round | 06/09/2021 | SD Huesca | - | Real Oviedo | 1:2 | ||||
| 5. Round | 13/09/2021 | CD Lugo | - | SD Huesca | 3:2 | ||||
| 6. Round | 19/09/2021 | SD Huesca | - | CF Fuenlabrada | 0:0 | ||||
| 7. Round | 24/09/2021 | Real Sociedad B | - | SD Huesca | 0:2 | ||||
| 8. Round | 02/10/2021 | SD Huesca | - | CD Tenerife | 1:2 | ||||
| 11. Round | 19/10/2021 | SD Huesca | - | Málaga CF | 0:0 | ||||
| 12. Round | 24/10/2021 | Burgos CF | - | SD Huesca | 3:1 | ||||
| 13. Round | 30/10/2021 | SD Huesca | - | SD Amorebieta | 1:1 | ||||
| 15. Round | 05/11/2021 | SD Huesca | - | CD Leganés | 0:2 | ||||
| 16. Round | 13/11/2021 | CD Mirandés | - | SD Huesca | 0:1 | ||||
| 18. Round | 27/11/2021 | UD Almería | - | SD Huesca | 0:0 | ||||
| 22. Round | 02/01/2022 | SD Huesca | - | Girona FC | 0:1 | ||||
| 23. Round | 08/01/2022 | FC Cartagena | - | SD Huesca | 0:3 |  |
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| 24. Round | 23/01/2022 | SD Huesca | - | SD Ponferradina | 1:2 | ||||
| 29. Round | 26/02/2022 | UD Ibiza | - | SD Huesca | 2:1 | ||||
| 33. Round | 27/03/2022 | Málaga CF | - | SD Huesca | 0:2 | ||||
| 41. Round | 21/05/2022 | SD Huesca | - | Real Sociedad B | 3:2 |  |
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| 42. Round | 29/05/2022 | Real Valladolid | - | SD Huesca | 3:0 |
Spain