| 10. Round | 03/09/2021 | Rosario Central II | - | Boca Juniors II | 1:3 | ||||
| 15. Round | 08/10/2021 | Estudiantes II | - | Rosario Central II | 1:1 | ||||
| 16. Round | 13/10/2021 | Rosario Central II | - | Patronato de Paraná II | 2:1 | ||||
| 19. Round | 29/10/2021 | Unión de Santa Fe II | - | Rosario Central II | 0:0 | ||||
| 20. Round | 05/11/2021 | Defensa y Justicia II | - | Rosario Central II | 1:2 | ||||
| 21. Round | 20/11/2021 | Rosario Central II | - | Atlético Tucumán II | 4:1 | ||||
| 23. Round | 28/11/2021 | Rosario Central II | - | River Plate II | 2:0 | ||||
| 24. Round | 03/12/2021 | Lanús II | - | Rosario Central II | 2:3 | ||||
| 25. Round | 10/12/2021 | Rosario Central II | - | Huracán II | 2:0 |
Argentina