| 1. Round | 03/09/2022 | FC Cartagena B | - | Real Betis B | 0:1 | ||||
| 2. Round | 11/09/2022 | Real Betis B | - | Mar Menor CF | 0:1 | ||||
| 3. Round | 18/09/2022 | Recreativo Huelva | - | Real Betis B | 2:4 |  |
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| 4. Round | 25/09/2022 | Real Betis B | - | Sevilla Atlético | 1:0 | |
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| 18. Round | 22/01/2023 | Real Betis B | - | FC Cartagena B | 2:0 | ||||
| 19. Round | 29/01/2023 | Mar Menor CF | - | Real Betis B | 1:0 | ||||
| 29. Round | 09/04/2023 | Utrera CD | - | Real Betis B | 1:4 | ||||
| 30. Round | 16/04/2023 | Atlético Sanluqueño CF | - | Real Betis B | 2:0 | ||||
| 31. Round | 23/04/2023 | Real Betis B | - | Cádiz CF B | 3:1 | |
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| 33. Round | 07/05/2023 | Real Betis B | - | CD El Ejido 2012 | 1:2 |
Argentina