| 15. Round | 13/12/1980 | Hércules CF | - | Athletic Club | 1:2 | ||||
| 16. Round | 20/12/1980 | Sevilla FC | - | Hércules CF | 0:0 | ||||
| 17. Round | 27/12/1980 | Hércules CF | - | Real Murcia | 1:0 | ||||
| 18. Round | 03/01/1981 | Hércules CF | - | Espanyol Barcelona | 2:0 | ||||
| 23. Round | 07/02/1981 | Real Sociedad | - | Hércules CF | 1:1 | ||||
| 25. Round | 21/02/1981 | Atlético Madrid | - | Hércules CF | 1:0 | ||||
| 26. Round | 28/02/1981 | FC Barcelona | - | Hércules CF | 6:0 | ||||
| 27. Round | 07/03/1981 | Hércules CF | - | UD Salamanca | 3:2 |  |
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| 28. Round | 14/03/1981 | Real Zaragoza | - | Hércules CF | 1:1 | ||||
| 30. Round | 28/03/1981 | Real Valladolid | - | Hércules CF | 2:1 | ||||
| 31. Round | 04/04/1981 | Hércules CF | - | AD Almería | 1:0 | ||||
| 32. Round | 11/04/1981 | Athletic Club | - | Hércules CF | 5:3 | ||||
| 33. Round | 18/04/1981 | Hércules CF | - | Sevilla FC | 5:1 | ||||
| 34. Round | 25/04/1981 | Real Murcia | - | Hércules CF | 2:2 |
Spain