| 1. Round | 16/08/2024 | Leicester City U21 | - | Southampton FC U21 | 1:2 | ||||
| 2. Round | 23/08/2024 | West Ham United U21 | - | Southampton FC U21 | 5:1 | ||||
| 4. Round | 20/09/2024 | Southampton FC U21 | - | Norwich City U21 | 2:3 | ||||
| 6. Round | 04/10/2024 | Nottingham Forest U21 | - | Southampton FC U21 | 0:2 |  |
|||
| 16. Round | 21/02/2025 | Southampton FC U21 | - | Sunderland AFC U21 | 3:3 | ||||
| 17. Round | 28/02/2025 | Southampton FC U21 | - | Wolverhampton Wanderers U21 | 2:1 | ||||
| 18. Round | 16/03/2025 | Middlesbrough FC U21 | - | Southampton FC U21 | 1:0 | ||||
| 19. Round | 04/04/2025 | Southampton FC U21 | - | Blackburn Rovers U21 | 3:0 | ||||
| 20. Round | 11/04/2025 | Derby County U21 | - | Southampton FC U21 | 0:0 |
Spain