| 1. Round | 15/08/2021 | Liverpool FC U23 | - | Manchester City U23 | 0:0 | ||||
| 2. Round | 20/08/2021 | Manchester City U23 | - | Blackburn Rovers U23 | 4:2 | ||||
| 3. Round | 28/08/2021 | Manchester United U23 | - | Manchester City U23 | 2:4 | ||||
| 4. Round | 11/09/2021 | Manchester City U23 | - | Chelsea FC U23 | 4:1 | ||||
| 5. Round | 18/09/2021 | Manchester City U23 | - | Crystal Palace U23 | 4:2 |  |
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| 18. Round | 24/01/2022 | Chelsea FC U23 | - | Manchester City U23 | 0:1 | ||||
| 19. Round | 07/02/2022 | Derby County U23 | - | Manchester City U23 | 0:5 | ||||
| 20. Round | 20/02/2022 | Manchester City U23 | - | West Ham United U23 | 2:0 | |
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| 21. Round | 28/02/2022 | Leicester City U23 | - | Manchester City U23 | 0:0 |
Spain