| 1° División | 23/01/21 | Mazatlán FC | - | Santos Laguna | 0:0 | ||||
| 1° División | 15/02/21 | Santos Laguna | - | CF Monterrey | 1:0 |  |
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| 1° División | 14/03/21 | Club Tijuana | - | Santos Laguna | 0:1 | ||||
| 1° División | 20/09/21 | Santos Laguna | - | Puebla FC | 1:1 | ||||
| 1° División | 21/11/21 | Santos Laguna | - | Atlético San Luis | 2:0 | ||||
| 1° División | 16/01/22 | Deportivo Toluca | - | Santos Laguna | 3:1 |
Colombia