| 1° División | 01/03/21 | Santos Laguna | - | FC Juárez | 3:2 | ||||
| 1° División | 19/04/21 | Santos Laguna | - | Deportivo Toluca | 3:1 |  |
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| 1° División | 16/08/21 | Santos Laguna | - | Deportivo Guadalajara | 0:0 | ||||
| 1° División | 11/09/21 | Club Tijuana | - | Santos Laguna | 2:1 |  |
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| 1° División | 29/11/21 | UANL Tigres | - | Santos Laguna | 1:0 | ||||
| 1° División | 13/02/22 | Santos Laguna | - | CF América | 2:3 | ||||
| 1° División | 11/05/22 | Puebla FC | - | CF América | 1:1 |
Colombia