| 19. Round | 23/01/2022 | Atlético Baleares | - | Algeciras CF | 2:1 | ||||
| 20. Round | 26/01/2022 | Algeciras CF | - | UE Cornellà | 3:2 |  |
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| 21. Round | 29/01/2022 | FC Andorra | - | Algeciras CF | 1:0 | ||||
| 22. Round | 05/02/2022 | Algeciras CF | - | FC Barcelona B | 2:1 | |
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| 23. Round | 13/02/2022 | Gimnàstic de Tarragona | - | Algeciras CF | 1:0 | ||||
| 25. Round | 27/02/2022 | Atlético Sanluqueño CF | - | Algeciras CF | 0:2 | ||||
| 27. Round | 13/03/2022 | Real Betis B | - | Algeciras CF | 2:3 | ||||
| 29. Round | 26/03/2022 | Algeciras CF | - | Linares Deportivo | 0:0 | ||||
| 30. Round | 02/04/2022 | Villarreal CF B | - | Algeciras CF | 3:0 | ||||
| 31. Round | 10/04/2022 | Algeciras CF | - | Atlético Baleares | 1:1 | ||||
| 32. Round | 15/04/2022 | UE Costa Brava | - | Algeciras CF | 0:1 | |
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| 34. Round | 29/04/2022 | CD Castellón | - | Algeciras CF | 1:0 | ||||
| 35. Round | 07/05/2022 | Algeciras CF | - | Sevilla Atlético | 3:0 |  |
Spain