6. Round | 03/10/2021 | Real Betis B | - | Atlético Sanluqueño CF | 0:3 | ||||
8. Round | 16/10/2021 | Real Betis B | - | Villarreal CF B | 1:2 | ||||
9. Round | 23/10/2021 | Algeciras CF | - | Real Betis B | 1:1 | ||||
10. Round | 30/10/2021 | Real Betis B | - | UE Costa Brava | 2:0 | ||||
13. Round | 19/11/2021 | Real Betis B | - | RB Linense | 1:2 | ||||
14. Round | 27/11/2021 | CD Castellón | - | Real Betis B | 2:1 | ||||
15. Round | 04/12/2021 | Real Betis B | - | Linares Deportivo | 1:3 | ||||
17. Round | 18/12/2021 | Real Betis B | - | Real Madrid Castilla | 0:3 |