| 5. Round | 04/09/2021 | EA Guingamp B | - | Stade Plabennec | 2:1 | ||||
| 7. Round | 18/09/2021 | EA Guingamp B | - | Blois Foot 41 | 2:3 | ||||
| 8. Round | 25/09/2021 | FC Lorient B | - | EA Guingamp B | 3:0 | ||||
| 9. Round | 09/10/2021 | EA Guingamp B | - | SM Caen B | 1:1 |  |
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| 10. Round | 23/10/2021 | EA Guingamp B | - | AS Poissy | 1:1 | ||||
| 11. Round | 06/11/2021 | C'Chartres Football | - | EA Guingamp B | 1:2 | |
France