| 7. Round | 03/10/2021 | AS Cannes [Youth] | - | AS Saint-Étienne [Youth] | 1:1 | ||||
| 9. Round | 16/10/2021 | OGC Nice [Youth] | - | AS Saint-Étienne [Youth] | 4:3 | ||||
| 10. Round | 23/10/2021 | AS Saint-Étienne [Youth] | - | Nîmes Olympique [Youth] | 2:0 | ||||
| 12. Round | 21/11/2021 | AS Saint-Étienne [Youth] | - | Montpellier HSC [Youth] | 0:0 | ||||
| 14. Round | 05/12/2021 | Pieve di Lota [Youth] | - | AS Saint-Étienne [Youth] | 1:7 | ||||
| 13. Round | 19/12/2021 | AS Saint-Étienne [Youth] | - | FC Istres [Youth] | 0:1 | ||||
| 15. Round | 16/01/2022 | AS Saint-Étienne [Youth] | - | SC Toulon [Youth] | 4:2 | ||||
| 17. Round | 06/02/2022 | AS Saint-Étienne [Youth] | - | Olympique Marseille [Youth] | 3:1 | ||||
| 18. Round | 13/02/2022 | US Colomiers [Youth] | - | AS Saint-Étienne [Youth] | 0:0 | ||||
| 21. Round | 26/03/2022 | AS Saint-Étienne [Youth] | - | OGC Nice [Youth] | 2:2 | ||||
| 24. Round | 17/04/2022 | Montpellier HSC [Youth] | - | AS Saint-Étienne [Youth] | 2:4 |
France