| 9. Round | 21/11/2021 | GPSO 92 Issy [Women] | - | Olympique Lyonnais [Women] | 0:4 | ||||
| 10. Round | 04/12/2021 | GPSO 92 Issy [Women] | - | Paris Saint-Germain [Women] | 0:3 | ||||
| 12. Round | 15/01/2022 | Paris FC [Women] | - | GPSO 92 Issy [Women] | 1:0 | ||||
| 13. Round | 22/01/2022 | GPSO 92 Issy [Women] | - | EA Guingamp [Women] | 0:2 | ||||
| 15. Round | 26/02/2022 | GPSO 92 Issy [Women] | - | ASJ Soyaux [Women] | 5:1 | ||||
| 16. Round | 12/03/2022 | Dijon FCO [Women] | - | GPSO 92 Issy [Women] | 0:1 | ||||
| 17. Round | 19/03/2022 | GPSO 92 Issy [Women] | - | AS Saint-Étienne [Women] | 4:1 | ||||
| 18. Round | 02/04/2022 | Girondins Bordeaux [Women] | - | GPSO 92 Issy [Women] | 3:0 | ||||
| 19. Round | 16/04/2022 | Paris Saint-Germain [Women] | - | GPSO 92 Issy [Women] | 6:1 |  |
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| 20. Round | 07/05/2022 | GPSO 92 Issy [Women] | - | FC Fleury 91 [Women] | 0:5 | ||||
| 22. Round | 01/06/2022 | Olympique Lyonnais [Women] | - | GPSO 92 Issy [Women] | 4:0 |
France