| 1. Round | 27/07/2012 | O'Higgins | - | Cerro Porteño | 3:3 |  |
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| 1. Round | 09/08/2012 | Cerro Porteño | - | O'Higgins | 4:0 | ||||
| 2. Round | 30/08/2012 | Mineros de Guayana | - | Cerro Porteño | 2:2 | |
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| 2. Round | 20/09/2012 | Cerro Porteño | - | Mineros de Guayana | 4:0 | ||||
| Round of 16 | 28/09/2012 | Colón de Santa Fe | - | Cerro Porteño | 1:2 | ||||
| Round of 16 | 23/10/2012 | Cerro Porteño | - | Colón de Santa Fe | 2:1 | |
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| Quarter-finals | 01/11/2012 | Cerro Porteño | - | Tigre | 1:0 | ||||
| Quarter-finals | 09/11/2012 | Tigre | - | Cerro Porteño | 4:2 |
Paraguay
Spain