| 2. Round | 29/08/2021 | Nîmes Olympique [Youth] | - | AS Cannes [Youth] | 0:2 | ||||
| 3. Round | 05/09/2021 | OGC Nice [Youth] | - | Nîmes Olympique [Youth] | 1:1 | ||||
| 4. Round | 12/09/2021 | Nîmes Olympique [Youth] | - | Toulouse FC [Youth] | 0:1 | ||||
| 6. Round | 26/09/2021 | Nîmes Olympique [Youth] | - | Pieve di Lota [Youth] | 4:1 | ||||
| 9. Round | 17/10/2021 | AC Ajaccio [Youth] | - | Nîmes Olympique [Youth] | 3:0 | ||||
| 10. Round | 23/10/2021 | AS Saint-Étienne [Youth] | - | Nîmes Olympique [Youth] | 2:0 | ||||
| 11. Round | 14/11/2021 | Nîmes Olympique [Youth] | - | Montpellier HSC [Youth] | 1:3 | ||||
| 12. Round | 21/11/2021 | AS Béziers [Youth] | - | Nîmes Olympique [Youth] | 3:0 | ||||
| 13. Round | 28/11/2021 | Nîmes Olympique [Youth] | - | SC Toulon [Youth] | 0:2 | ||||
| 14. Round | 05/12/2021 | AS Cannes [Youth] | - | Nîmes Olympique [Youth] | 6:1 | ||||
| 18. Round | 13/02/2022 | Pieve di Lota [Youth] | - | Nîmes Olympique [Youth] | 0:5 |
France