1. Round | 14/08/2021 | İstanbulspor AŞ | - | Manisa FK | 3:4 | ||||
3. Round | 29/08/2021 | Gençlerbirliği | - | Manisa FK | 0:3 | ||||
4. Round | 11/09/2021 | Manisa FK | - | BB Erzurumspor | 0:1 | ||||
6. Round | 18/09/2021 | Manisa FK | - | Bandırmaspor | 1:3 | ||||
7. Round | 25/09/2021 | Ümraniyespor | - | Manisa FK | 1:0 | ||||
8. Round | 03/10/2021 | Eyüpspor | - | Manisa FK | 3:2 | ||||
9. Round | 17/10/2021 | Manisa FK | - | Adanaspor | 0:3 | ||||
13. Round | 21/11/2021 | Manisa FK | - | Altınordu FK | 1:0 | ||||
14. Round | 26/11/2021 | Balıkesirspor | - | Manisa FK | 0:0 | ||||
15. Round | 05/12/2021 | Manisa FK | - | Kocaelispor | 2:1 | ||||
17. Round | 14/12/2021 | Manisa FK | - | Keçiörengücü | 1:1 | ||||
18. Round | 19/12/2021 | Tuzlaspor | - | Manisa FK | 0:1 |