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| 18/12/2021 | 10:30 | Keçiörengücü | - | BB Erzurumspor | 3:3 (0:1) | |
| 13:00 | Boluspor | - | MKE Ankaragücü | 0:2 (0:1) | ||
| 16:00 | Balıkesirspor | - | Altınordu FK | 3:4 (0:2) | ||
| 19/12/2021 | 10:30 | Gençlerbirliği | - | Menemen Belediyespor | 5:0 (1:0) | |
| 13:00 | Bursaspor | - | Bandırmaspor | 0:1 (0:0) | ||
| 13:00 | Tuzlaspor | - | Manisa FK | 0:1 (0:1) | ||
| 16:00 | Kocaelispor | - | Eyüpspor | 1:1 (0:1) | ||
| 20/12/2021 | 14:30 | İstanbulspor AŞ | - | Samsunspor | 2:1 (0:0) | |
| 17:00 | Denizlispor | - | Ümraniyespor | 0:1 (0:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Ümraniyespor | 17 | 11 | 3 | 3 | 31:14 | 17 | 36 |
| 2 |
|
BB Erzurumspor | 17 | 10 | 3 | 4 | 29:20 | 9 | 33 |
| 3 |
|
MKE Ankaragücü | 17 | 10 | 3 | 4 | 27:13 | 14 | 33 |
| 4 |
|
Bandırmaspor | 17 | 10 | 1 | 6 | 28:15 | 13 | 31 |
| 5 |
|
Eyüpspor | 17 | 9 | 4 | 4 | 28:21 | 7 | 31 |
| 6 |
|
İstanbulspor AŞ | 17 | 8 | 2 | 7 | 27:24 | 3 | 26 |
| 7 |
|
Samsunspor | 17 | 7 | 5 | 5 | 24:21 | 3 | 26 |
| 8 |
|
Gençlerbirliği | 17 | 8 | 2 | 7 | 22:22 | 0 | 26 |
| 9 |
|
Kocaelispor | 17 | 7 | 3 | 7 | 19:20 | -1 | 24 |
| 10 |
|
Tuzlaspor | 17 | 6 | 5 | 6 | 17:16 | 1 | 23 |
| 11 |
|
Adanaspor | 17 | 6 | 5 | 6 | 18:19 | -1 | 23 |
| 12 |
|
Manisa FK | 18 | 6 | 4 | 8 | 20:24 | -4 | 22 |
| 13 |
|
Boluspor | 17 | 5 | 6 | 6 | 19:19 | 0 | 21 |
| 14 |
|
Menemen Belediyespor | 17 | 5 | 5 | 7 | 21:31 | -10 | 20 |
| 15 |
|
Keçiörengücü | 17 | 5 | 4 | 8 | 23:28 | -5 | 19 |
| 16 |
|
Altınordu FK | 17 | 6 | 1 | 10 | 22:34 | -12 | 19 |
| 17 |
|
Bursaspor | 17 | 5 | 3 | 9 | 22:28 | -6 | 18 |
| 18 |
|
Denizlispor | 17 | 4 | 4 | 9 | 14:23 | -9 | 16 |
| 19 |
|
Balıkesirspor | 17 | 2 | 1 | 14 | 13:32 | -19 | 7 |
| Promotion | |
| Playoffs | |
| Relegation |
