| 1. Round | 29/08/2021 | EA Guingamp [Youth B] | - | Angoulême CFC [Youth B] | 5:1 | ||||
| 2. Round | 05/09/2021 | Vannes OC [Youth B] | - | EA Guingamp [Youth B] | 0:3 | ||||
| 5. Round | 26/09/2021 | EA Guingamp [Youth B] | - | LB Châteauroux [Youth B] | 0:0 | ||||
| 6. Round | 02/10/2021 | SO Cholet [Youth B] | - | EA Guingamp [Youth B] | 1:1 | ||||
| 8. Round | 16/10/2021 | Stade Rennais [Youth B] | - | EA Guingamp [Youth B] | 2:0 | ||||
| 9. Round | 24/10/2021 | EA Guingamp [Youth B] | - | Stade brestois 29 [Youth B] | 0:4 | ||||
| 15. Round | 27/02/2022 | FC Nantes [Youth B] | - | EA Guingamp [Youth B] | 4:0 | ||||
| 18. Round | 05/03/2022 | EA Guingamp [Youth B] | - | SO Cholet [Youth B] | 2:0 | ||||
| 23. Round | 09/04/2022 | USSA Vertou [Youth B] | - | EA Guingamp [Youth B] | 2:2 | ||||
| 24. Round | 17/04/2022 | La Roche VF [Youth B] | - | EA Guingamp [Youth B] | 0:2 | ||||
| 26. Round | 15/05/2022 | Angoulême CFC [Youth B] | - | EA Guingamp [Youth B] | 1:4 |
France