| 3. Round | 07/08/2021 | UANL Tigres [U18] | - | Santos Laguna [U18] | 0:0 | ||||
| 4. Round | 13/08/2021 | Puebla FC [U18] | - | UANL Tigres [U18] | 1:2 | ||||
| 5. Round | 17/08/2021 | UANL Tigres [U18] | - | Gallos Blancos [U18] | 1:0 | ||||
| 6. Round | 20/08/2021 | Mazatlán FC [U18] | - | UANL Tigres [U18] | 0:4 | ||||
| 7. Round | 28/08/2021 | UANL Tigres [U18] | - | Atlas Guadalajara [U18] | 0:0 | ||||
| 8. Round | 11/09/2021 | UANL Tigres [U18] | - | Club León [U18] | 1:1 | ||||
| 9. Round | 19/09/2021 | CF Monterrey [U18] | - | UANL Tigres [U18] | 0:1 | ||||
| 10. Round | 25/09/2021 | UANL Tigres [U18] | - | Pumas UNAM [U18] | 6:0 | ||||
| 11. Round | 29/09/2021 | Atlético San Luis [U18] | - | UANL Tigres [U18] | 0:5 |  |
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| 12. Round | 03/10/2021 | UANL Tigres [U18] | - | Club Necaxa [U18] | 1:1 | ||||
| 13. Round | 16/10/2021 | Cruz Azul [U18] | - | UANL Tigres [U18] | 0:1 | ||||
| 14. Round | 20/10/2021 | UANL Tigres [U18] | - | CF Pachuca [U18] | 3:2 | ||||
| 15. Round | 23/10/2021 | CF América [U18] | - | UANL Tigres [U18] | 3:3 | ||||
| 16. Round | 30/10/2021 | UANL Tigres [U18] | - | Deportivo Guadalajara [U18] | 1:3 | ||||
| 17. Round | 06/11/2021 | UANL Tigres [U18] | - | FC Juárez [U18] | 2:0 |
Mexico