| 1. Round | 07/08/2021 | RC Grasse | - | Lyon-La Duchère | 1:0 | ||||
| 2. Round | 14/08/2021 | Lyon-La Duchère | - | Louhans-Cuiseaux | 1:3 | ||||
| 3. Round | 21/08/2021 | Hyères FC | - | Lyon-La Duchère | 0:0 | ||||
| 4. Round | 27/08/2021 | SC Toulon | - | Lyon-La Duchère | 0:2 | ||||
| 5. Round | 04/09/2021 | Lyon-La Duchère | - | AS Monaco B | 0:2 | ||||
| 6. Round | 11/09/2021 | FC Martigues | - | Lyon-La Duchère | 0:3 | ||||
| 7. Round | 18/09/2021 | Lyon-La Duchère | - | GFA Rumilly Vallières | 0:0 | ||||
| 8. Round | 25/09/2021 | AS Saint-Priest | - | Lyon-La Duchère | 1:2 |  |
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| 9. Round | 09/10/2021 | Lyon-La Duchère | - | Étoile FC | 0:1 | ||||
| 16. Round | 22/01/2022 | Louhans-Cuiseaux | - | Lyon-La Duchère | 1:0 | ||||
| 26. Round | 23/04/2022 | Lyon-La Duchère | - | Jura Sud | 1:4 | ||||
| 27. Round | 30/04/2022 | Olympique Marseille B | - | Lyon-La Duchère | 2:1 | ||||
| 28. Round | 14/05/2022 | Lyon-La Duchère | - | Marignane Gignac FC | 3:1 |
France