| 1. Round | 22/08/2021 | AS Béziers [Youth] | - | AS Saint-Étienne [Youth] | 2:6 |  |
|||
| 2. Round | 29/08/2021 | AS Saint-Étienne [Youth] | - | Pieve di Lota [Youth] | 11:0 | ||||
| 4. Round | 12/09/2021 | AS Saint-Étienne [Youth] | - | AS Monaco [Youth] | 2:0 | |
|||
| 5. Round | 19/09/2021 | Olympique Marseille [Youth] | - | AS Saint-Étienne [Youth] | 0:2 | ||||
| 11. Round | 14/11/2021 | Toulouse FC [Youth] | - | AS Saint-Étienne [Youth] | 0:1 | ||||
| 12. Round | 21/11/2021 | AS Saint-Étienne [Youth] | - | Montpellier HSC [Youth] | 0:0 |
France