| 12. Round | 20/11/2021 | US Saint-Malo | - | AS Vitré | 1:0 | ||||
| 13. Round | 04/12/2021 | AS Vitré | - | Stade Plabennec | 1:0 |  |
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| 14. Round | 11/12/2021 | St-Pryvé St-Hilaire | - | AS Vitré | 1:1 | ||||
| 15. Round | 15/01/2022 | AS Vitré | - | Blois Foot 41 | 4:1 | |
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| 16. Round | 22/01/2022 | EA Guingamp B | - | AS Vitré | 0:5 | ||||
| 17. Round | 05/02/2022 | AS Vitré | - | AS Poissy | 1:1 | ||||
| 18. Round | 12/02/2022 | C'Chartres Football | - | AS Vitré | 5:2 |  |
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| 22. Round | 19/03/2022 | SO Romorantin | - | AS Vitré | 1:1 | ||||
| 23. Round | 26/03/2022 | AS Vitré | - | FC Rouen 1899 | 2:2 | ||||
| 24. Round | 09/04/2022 | AS Vitré | - | SM Caen B | 2:0 | ||||
| 25. Round | 16/04/2022 | FC Versailles | - | AS Vitré | 3:0 | ||||
| 26. Round | 23/04/2022 | AS Vitré | - | US Saint-Malo | 2:2 | ||||
| 27. Round | 30/04/2022 | Stade Plabennec | - | AS Vitré | 2:2 | ||||
| 28. Round | 14/05/2022 | AS Vitré | - | St-Pryvé St-Hilaire | 0:3 | ||||
| 29. Round | 21/05/2022 | Blois Foot 41 | - | AS Vitré | 5:4 | ||||
| 30. Round | 28/05/2022 | AS Vitré | - | FC Lorient B | 0:5 |
France