| 1. Round | 07/08/2021 | FC Chamalières | - | Vendée Les Herbiers | 1:1 | ||||
| 2. Round | 14/08/2021 | Montpellier HSC B | - | FC Chamalières | 1:2 | ||||
| 5. Round | 04/09/2021 | US Colomiers | - | FC Chamalières | 2:0 | ||||
| 6. Round | 11/09/2021 | FC Chamalières | - | FC Nantes B | 2:2 |  |
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| 7. Round | 18/09/2021 | Canet Roussillon | - | FC Chamalières | 2:0 | ||||
| 8. Round | 25/09/2021 | FC Chamalières | - | Angoulême CFC | 1:2 | |
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| 10. Round | 23/10/2021 | FC Chamalières | - | Moulins Yzeure Foot | 3:0 | ||||
| 15. Round | 15/01/2022 | Angers SCO B | - | FC Chamalières | 1:1 | ||||
| 16. Round | 22/01/2022 | FC Chamalières | - | Montpellier HSC B | 1:2 | |
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| 17. Round | 04/02/2022 | Bergerac Périgord FC | - | FC Chamalières | 1:0 | |
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| 18. Round | 12/02/2022 | Andrézieux-Bouthéon FC | - | FC Chamalières | 0:0 | ||||
| 19. Round | 19/02/2022 | FC Chamalières | - | US Colomiers | 2:0 | ||||
| 28. Round | 14/05/2022 | Le Puy Foot 43 | - | FC Chamalières | 1:0 | |
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| 29. Round | 21/05/2022 | FC Chamalières | - | Angers SCO B | 1:0 |
France