| 1. Round | 25/07/2021 | Pumas UNAM [U18] | - | Atlas Guadalajara [U18] | 1:2 | ||||
| 8. Round | 11/09/2021 | Atlas Guadalajara [U18] | - | CF Monterrey [U18] | 4:0 | ||||
| 9. Round | 17/09/2021 | Club Necaxa [U18] | - | Atlas Guadalajara [U18] | 1:0 | ||||
| 10. Round | 25/09/2021 | Atlas Guadalajara [U18] | - | Club León [U18] | 2:3 |  |
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| 11. Round | 28/09/2021 | Atlas Guadalajara [U18] | - | Puebla FC [U18] | 2:2 | |
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| 12. Round | 02/10/2021 | Deportivo Guadalajara [U18] | - | Atlas Guadalajara [U18] | 3:0 | ||||
| 13. Round | 15/10/2021 | Mazatlán FC [U18] | - | Atlas Guadalajara [U18] | 1:1 | ||||
| 14. Round | 19/10/2021 | Atlas Guadalajara [U18] | - | Cruz Azul [U18] | 5:2 | ||||
| 15. Round | 24/10/2021 | Atlético San Luis [U18] | - | Atlas Guadalajara [U18] | 0:1 | ||||
| 16. Round | 28/10/2021 | Atlas Guadalajara [U18] | - | Club Tijuana [U18] | 1:0 | ||||
| 17. Round | 04/11/2021 | Atlas Guadalajara [U18] | - | Gallos Blancos [U18] | 2:1 |
Mexico