| 3. Round | 21/02/2022 | Boca Juniors II | - | Rosario Central II | 0:0 | ||||
| 4. Round | 26/02/2022 | Rosario Central II | - | Godoy Cruz II | 5:1 | ||||
| 5. Round | 04/03/2022 | Central Córdoba SdE II | - | Rosario Central II | 0:3 | ||||
| 6. Round | 11/03/2022 | Rosario Central II | - | Barracas Central II | 1:2 | ||||
| 7. Round | 18/03/2022 | Rosario Central II | - | Newell's Old Boys II | 2:1 | ||||
| 8. Round | 01/04/2022 | Tigre II | - | Rosario Central II | 1:3 | ||||
| 9. Round | 07/04/2022 | Rosario Central II | - | Colón de Santa Fe II | 3:1 | ||||
| 10. Round | 14/04/2022 | Aldosivi II | - | Rosario Central II | 1:0 | ||||
| 11. Round | 19/04/2022 | Lanús II | - | Rosario Central II | 1:0 | ||||
| 12. Round | 25/04/2022 | Rosario Central II | - | Independiente II | 1:2 | ||||
| 13. Round | 29/04/2022 | Huracán II | - | Rosario Central II | 3:0 | ||||
| 14. Round | 05/05/2022 | Rosario Central II | - | Estudiantes II | 0:1 |
Argentina