| 17. Round | 17/01/2022 | Crystal Palace U23 | - | Chelsea FC U23 | 3:2 | ||||
| 19. Round | 07/02/2022 | Tottenham Hotspur U23 | - | Crystal Palace U23 | 1:4 | ||||
| 20. Round | 20/02/2022 | Crystal Palace U23 | - | Manchester United U23 | 2:2 | ||||
| 21. Round | 28/02/2022 | Crystal Palace U23 | - | Brighton & Hove Albion U23 | 2:0 | ||||
| 22. Round | 12/03/2022 | Crystal Palace U23 | - | Manchester City U23 | 1:2 | ||||
| 23. Round | 19/03/2022 | Crystal Palace U23 | - | Arsenal FC U23 | 1:1 | ||||
| 24. Round | 04/04/2022 | Leeds United U23 | - | Crystal Palace U23 | 4:0 | ||||
| 25. Round | 25/04/2022 | Blackburn Rovers U23 | - | Crystal Palace U23 | 2:1 | ||||
| 26. Round | 02/05/2022 | Crystal Palace U23 | - | Leicester City U23 | 3:2 |  |
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| 15. Round | 09/05/2022 | Crystal Palace U23 | - | Derby County U23 | 3:1 |
USA