| 1. Round | 29/08/2021 | Le Mans FC [Youth B] | - | FC Rouen 1899 [Youth B] | 4:1 | ||||
| 2. Round | 04/09/2021 | Montrouge FC [Youth B] | - | Le Mans FC [Youth B] | 1:0 | ||||
| 3. Round | 12/09/2021 | Le Mans FC [Youth B] | - | Paris FC [Youth B] | 1:3 | ||||
| 4. Round | 19/09/2021 | US Orléans [Youth B] | - | Le Mans FC [Youth B] | 5:1 |  |
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| 5. Round | 26/09/2021 | Le Mans FC [Youth B] | - | Tours FC [Youth B] | 2:0 | |
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| 6. Round | 03/10/2021 | CS Brétigny [Youth B] | - | Le Mans FC [Youth B] | 2:1 | ||||
| 7. Round | 10/10/2021 | Le Mans FC [Youth B] | - | FC Mantois [Youth B] | 0:1 | ||||
| 8. Round | 17/10/2021 | Havre AC [Youth B] | - | Le Mans FC [Youth B] | 6:0 | ||||
| 9. Round | 23/10/2021 | Le Mans FC [Youth B] | - | Blois Foot 41 [Youth B] | 2:2 | ||||
| 12. Round | 27/11/2021 | Le Mans FC [Youth B] | - | SM Caen [Youth B] | 1:3 | ||||
| 13. Round | 05/12/2021 | AS Vitré [Youth B] | - | Le Mans FC [Youth B] | 4:3 | ||||
| 14. Round | 16/01/2022 | Le Mans FC [Youth B] | - | Montrouge FC [Youth B] | 4:2 | |
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| 15. Round | 23/01/2022 | Paris FC [Youth B] | - | Le Mans FC [Youth B] | 2:0 |
France