| 1. Round | 30/07/2022 | Nîmes Olympique | - | SM Caen | 0:1 |  |
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| 2. Round | 06/08/2022 | AS Saint-Étienne | - | Nîmes Olympique | 1:1 | ||||
| 3. Round | 13/08/2022 | Nîmes Olympique | - | Rodez AF | 1:0 | ||||
| 4. Round | 20/08/2022 | Dijon FCO | - | Nîmes Olympique | 2:1 | |
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| 5. Round | 27/08/2022 | Nîmes Olympique | - | Stade Lavallois | 1:0 | ||||
| 6. Round | 30/08/2022 | Grenoble Foot 38 | - | Nîmes Olympique | 3:2 | ||||
| 7. Round | 02/09/2022 | Valenciennes FC | - | Nîmes Olympique | 3:2 | ||||
| 8. Round | 10/09/2022 | Nîmes Olympique | - | SC Bastia | 0:0 | ||||
| 9. Round | 17/09/2022 | FC Sochaux | - | Nîmes Olympique | 3:1 | ||||
| 10. Round | 01/10/2022 | Nîmes Olympique | - | Paris FC | 0:1 | ||||
| 11. Round | 08/10/2022 | US Quevilly-Rouen | - | Nîmes Olympique | 3:1 | |
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| 12. Round | 15/10/2022 | Nîmes Olympique | - | Amiens SC | 2:0 | |
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| 13. Round | 22/10/2022 | Pau FC | - | Nîmes Olympique | 1:0 | ||||
| 14. Round | 05/11/2022 | Nîmes Olympique | - | Girondins Bordeaux | 1:0 | ||||
| 15. Round | 12/11/2022 | Chamois Niortais | - | Nîmes Olympique | 1:1 | ||||
| 16. Round | 26/12/2022 | Nîmes Olympique | - | EA Guingamp | 1:2 | ||||
| 18. Round | 10/01/2023 | Nîmes Olympique | - | FC Metz | 1:4 | |
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| 19. Round | 13/01/2023 | Havre AC | - | Nîmes Olympique | 3:1 |  |
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France
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