| 5. Round | 13/09/2008 | Valenciennes FC | - | Grenoble Foot 38 | 1:1 | ||||
| 6. Round | 20/09/2008 | Grenoble Foot 38 | - | Girondins Bordeaux | 0:1 | ||||
| 21. Round | 17/01/2009 | Grenoble Foot 38 | - | Olympique Lyonnais | 0:2 | ||||
| 22. Round | 31/01/2009 | AS Monaco | - | Grenoble Foot 38 | 1:0 | ||||
| 26. Round | 28/02/2009 | FC Nantes | - | Grenoble Foot 38 | 1:1 | ||||
| 27. Round | 07/03/2009 | Grenoble Foot 38 | - | SM Caen | 2:1 |  |
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| 28. Round | 15/03/2009 | Grenoble Foot 38 | - | AS Saint-Étienne | 1:0 | ||||
| 29. Round | 21/03/2009 | Lille OSC | - | Grenoble Foot 38 | 2:1 | ||||
| 30. Round | 04/04/2009 | Grenoble Foot 38 | - | FC Lorient | 1:3 | ||||
| 31. Round | 12/04/2009 | Olympique Marseille | - | Grenoble Foot 38 | 4:1 | ||||
| 32. Round | 18/04/2009 | Grenoble Foot 38 | - | Toulouse FC | 1:0 | ||||
| 33. Round | 26/04/2009 | Havre AC | - | Grenoble Foot 38 | 0:1 | ||||
| 34. Round | 02/05/2009 | Grenoble Foot 38 | - | OGC Nice | 0:0 |  |
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| 38. Round | 30/05/2009 | Grenoble Foot 38 | - | FC Sochaux | 0:1 |
France