| 17. Round | 06/11/1980 | RC Strasbourg | - | Olympique Lyonnais | 2:1 | ||||
| 21. Round | 06/12/1980 | AS Monaco | - | Olympique Lyonnais | 2:1 | ||||
| 22. Round | 13/12/1980 | Olympique Lyonnais | - | Nîmes Olympique | 4:2 | ||||
| 23. Round | 19/12/1980 | Stade Lavallois | - | Olympique Lyonnais | 0:0 | ||||
| 18. Round | 03/02/1981 | Olympique Lyonnais | - | Paris Saint-Germain | 2:0 | ||||
| 26. Round | 07/02/1981 | Olympique Lyonnais | - | FC Sochaux | 5:1 | ||||
| 27. Round | 21/02/1981 | AS Saint-Étienne | - | Olympique Lyonnais | 3:2 | ||||
| 29. Round | 13/03/1981 | Girondins Bordeaux | - | Olympique Lyonnais | 3:2 | ||||
| 30. Round | 27/03/1981 | Olympique Lyonnais | - | AS Nancy Lorraine | 4:2 | ||||
| 31. Round | 06/04/1981 | OGC Nice | - | Olympique Lyonnais | 3:2 | ||||
| 32. Round | 14/04/1981 | Angers SCO | - | Olympique Lyonnais | 1:3 | ||||
| 34. Round | 04/05/1981 | Lille OSC | - | Olympique Lyonnais | 1:1 | ||||
| 35. Round | 11/05/1981 | Olympique Lyonnais | - | RC Strasbourg | 0:0 | ||||
| 36. Round | 21/05/1981 | Paris Saint-Germain | - | Olympique Lyonnais | 1:1 | ||||
| 37. Round | 28/05/1981 | Olympique Lyonnais | - | AJ Auxerre | 1:3 |  |
France