| 4. Round | 25/02/2022 | Colón de Santa Fe II | - | Barracas Central II | 3:2 | ||||
| 5. Round | 03/03/2022 | Tigre II | - | Colón de Santa Fe II | 1:0 | ||||
| 7. Round | 17/03/2022 | Colón de Santa Fe II | - | Unión de Santa Fe II | 0:1 | ||||
| 8. Round | 31/03/2022 | Colón de Santa Fe II | - | Aldosivi II | 1:0 | ||||
| 10. Round | 13/04/2022 | Colón de Santa Fe II | - | Independiente II | 0:1 | ||||
| 11. Round | 18/04/2022 | Huracán II | - | Colón de Santa Fe II | 1:3 | ||||
| 14. Round | 06/05/2022 | Colón de Santa Fe II | - | Vélez Sarsfield II | 1:0 |
Argentina