| 2. Round | 08/06/2022 | Unión de Santa Fe II | - | Colón de Santa Fe II | 1:1 | ||||
| 3. Round | 14/06/2022 | River Plate II | - | Colón de Santa Fe II | 0:2 | ||||
| 4. Round | 19/06/2022 | Colón de Santa Fe II | - | Lanús II | 1:0 | ||||
| 11. Round | 31/07/2022 | Independiente II | - | Colón de Santa Fe II | 1:1 | ||||
| 14. Round | 15/08/2022 | Colón de Santa Fe II | - | Central Córdoba SdE II | 5:3 | ||||
| 23. Round | 04/10/2022 | Patronato de Paraná II | - | Colón de Santa Fe II | 1:2 | ||||
| 24. Round | 08/10/2022 | Colón de Santa Fe II | - | Platense II | 0:1 |  |
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| 25. Round | 12/10/2022 | Racing Club II | - | Colón de Santa Fe II | 2:2 | ||||
| 26. Round | 17/10/2022 | Defensa y Justicia II | - | Colón de Santa Fe II | 0:1 | ||||
| 27. Round | 23/10/2022 | Colón de Santa Fe II | - | Rosario Central II | 0:5 |
Argentina